This will be the first game for the Buccaneers without former first round pick Vernon Hargreaves as he was released earlier in the week and claimed by the Houston Texans.
The Bucs will also be without outside linebackers Anthony Nelson and Carl Nassib for the second consecutive week, as well as cornerback M.J. Stewart causing some depth issues at an already shallow position group.
The Bucs will, however, see the return of corner Carlton Davis who missed the last two games with a hip injury.
For the Saints, they are going to be without top corner Marshon Lattimore who was a big reason Mike Evans went without a reception in the first game between these two teams. They are also without guard Andrus Peat, which is a big blow to the interior of their offensive line.
Here are the full lists of inactive players for the Bucs and Saints;
Tampa Bay Buccaneers:
Outside Linebacker - Carl Nassib
Outside Linebacker - Anthony Nelson
Cornerback - M.J. Stewart
Tackle - Jerald hawkins
Tight End - Jordan Leggett
Guard - Aaron Stinnie
Cornerback - Mazzi Wilkins
New Orleans Saints:
Cornerback - Marshon Lattimore
Wide Receiver - Deonte Harris
Guard - Andrus Peat
Tackle - Ethan Greenidge
Wide Receiver - Austin Carr
Tight End - Dan Arnold
Defensive End - Carl Granderson
The Buccaneers and Saints kick off at 1:00 p.m. EST at Raymond James Stadium in Tampa