You know the drill. Let's see how we do this week. Feel free to leave your picks and prognostications below. Some interesting picks this week (a near-clean-sweep of the Raiders on the road against a defending division champion with Bruce Gradkowski running the offense (?!?)).
| Craig T | Sander | UNFNole | RyanL87 | Alstott40 | LeeCaz | LA_BUCS | |
| PIT @ TB | PIT | PIT | PIT | TB | PIT | TB | PIT |
| SF @ KC | KC | KC | KC | KC | SF | SF | SF |
| DET @ MIN | MIN | DET | MIN | DET | MIN | MIN | MIN |
| BUF @ NE | NE | NE | NE | NE | NE | NE | NE |
| TEN @ NYG | NYG | TEN | NYG | NYG | NYG | TEN | NYG |
| ATL @ NO | NO | NO | ATL | No pick | NO | NO | NO |
| CIN @ CAR | CIN | CIN | CIN | CIN | CIN | CIN | CIN |
| CLE @ BAL | BAL | BAL | BAL | BAL | BAL | BAL | BAL |
| DAL @ HOU | DAL | HOU | DAL | DAL | HOU | HOU | HOU |
| WAS @ STL | WAS | WAS | STL | WAS | WAS | WAS | WAS |
| PHI @ JAX | JAX | PHI | JAX | PHI | PHI | PHI | PHI |
| IND @ DEN | IND | IND | IND | IND | IND | IND | IND |
| OAK @ ARI | OAK | OAK | OAK | OAK | OAK | OAK | ARI |
| SD @ SEA | SEA | SD | SD | SD | SD | SD | SD |
| NYJ @ MIA | MIA | MIA | NYJ | NYJ | NYJ | MIA | MIA |
| GB @ CHI | CHI | GB | GB | CHI | GB | GB | CHI |